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KMID : 0613820190290060740
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Journal of Life Science
2019 Volume.29 No. 6 p.740 ~ p.746
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Effects of Exercise on Sleep Quality and Dementia-related Factors of Dementia Patients
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Yoon Byung-Kon
Kim Jong-Jin
Kwak Yi-Sub
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Abstract
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It is well known that exercise may have a positive effects on dementia. However, most of dementia-related studies were performed about symptom care, diverse treatment and drug treatment. Although regular physical exercise plays an important role of brain function and dementia prevention, only a few research studies showed the effect of physical exercise on dementia and brain function. This study is to investigate about the sleep-related factors (melatonin, serotonin), dementia-related factors (BDNF, beta-amyloid, IGF-1, Irisin, GLUT) with physical exercise. This study revealed that Myokine (Irisin, IGF-1), GLUT and Melatonin is an important factors to improve or sometimes delay the symptoms of dementia through BDNF activation following endurance exercise. However, these results were controversal following the various kinds of exercise type, mode, duration and exercise intensity and so forth. Therefore, further mechanism study about exercise and dementia is urgently needed in this area.
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KEYWORD
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BDNF, beta-amyloid, dementia, GLUT, irisin
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